Groups and Members

In this research area, as shown in Figure 2, the following four research items cooperatively collaborate with each other to introduce innovation in the field of catalytic synthetic organic chemistry. Intensive studies will be performed to install the appropriate functions of suitable steric and electronic properties into a specific field around a catalytically active site.

Executive Board Members

Head Investigator,
A04 Group Director
Kazushi Mashima
Division of Chemistry, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, Professor
Collaborative Research Manager,
A01 Group Director
Kyoko Nozaki
Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Professor
Public Relations Manager,
A02 Group Director
Nobuharu Iwasawa
Department of Chemistry, Tokyo Institute of Technology, Professor
Secretariat,
A03 Group Director
Takashi Hayashi
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Professor
Internationalization Manager Yoshiaki Nakao
Department of Material, Graduate School of Engineering, Kyoto University, Professor
Public Relations Manager Shigeki Matsunaga
Faculty of Pharmaceutical Sciences, Graduate School of Life Science, Hokkaido University, Professor
Internationalization Manager Osami Shoji
Department of Chemistry, Graduate School of Science, Nagoya University, Associate Professor

Advisory Board Members

Masakazu Iwamoto
Chuo University, RDI Professor; Tokyo Institute of Technology, Professor Emeritus; Hokkaido University, Professor Emeritus
Koichiro Oshima
Kyoto University, Vice President; Graduate School of Advanced Integrated Studies in Human Survivability, Professor
Naoto Chatani
Graduate School of Engineering, Osaka University, Professor
Tamejiro Hiyama
Chuo University, RDI Professor; Kyoto University; Professor Emeritus
Shunichi Fukuzumi
Faculty of Science and Technology, Meijo University, Specially Appointed Professor; Ewha Womans University, Distinguished Professor; Osaka University; Professor Emeritus
Keiji Maruoka
Graduate School of Science, Kyoto University, Professor
Masahiko Yamaguchi
Graduate School of Pharmaceutical Sciences, Tohoku University, Professor
Yoshihito Watanabe
Nagoya University, Vice President

Research Item A01: Development of Extremely Difficult Substrate Conversion

Board Members

  • Kyoko Nozaki (Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Professor)
    Development of Difficult Substrate Conversion Reaction toward Carbon Dioxide Utilization
  • Noritaka Mizuno (Department of Applied Chemistry, School of Engineering, The University of Tokyo, Professor)
    Development of High Performance Molecular Catalysts for Extremely Difficult Selective Oxidation Reactions
  • Yoshiaki Nishibayashi (Department of Systems Innovation, Graduate School of Engineering, The University of Tokyo, Professor)
    Development of Novel Transformations of Molecular Dinitrogen and Dihydrogen
  • Yoshiaki Nakao (Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Professor)
    Studies on Extremely Difficult Substrate Conversion Reactions through Activation of Unreactive Bonds

Participating Researchers

  • Itaru Nakamura (Research and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University, Associate Professor)
    High-level molecular transformation by precise control of catalytic skeletal rearrangement reactions
  • Yoshinori Kondo (Department of Molecular Transformation, Graduate School of Pharmaceutical Sciences, Tohoku University, Professor)
    Aromatic C-H Functionalization Using highly Reactive CsHMDS Amide Base
  • Yoshiharu Iwabuchi (Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Professor)
    Development of highly chemoseletive aerobic alcohol oxidation system based on AZADO-Cu cooperative catalysis
  • Hidetoshi Tokuyama (Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Professor)
    Development and application of environmentally benign oxidation process based on fine design of catalytic system using metal-phthalocyanine complexes
  • Seiji Mori (Department of Chemistry, Faculty of Science, Ibaraki University, Professor)
    Theoretical design of Extremely Difficult and Selective Substrate Conversion Reactions
  • Junji Ichikawa (Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Professor)
    Carbon-fluorine bond activation via fluorine eliminations
  • Hideki Amii (Division of Molecular Science, Graduate School of Science and Technology, Gunma University, Professor)
    Precisely Designed Catalyst Systems for Useful Transformation of Fluorocarbons
  • Laurean Ilies (Department of Chemistry, School of Science, The University of Tokyo, Associate Professor)
    Design of Iron Catalyst for Activation of Simple Arenes and Heteroarenes
  • Susumu Saito (Department of Chemistry, Graduate School of Science, Nagoya University, Professor)
    Catalytic dehydrative functionalization of amino acid- and peptide derivatives through elaborated hydrogen transfer processes
  • Ken-ichi Fujita (Department of Interdisciplinary Environment, Graduate School of Human and Environmental Studies, Kyoto University, Professor)
    Design and Synthesis of New Transition Metal Catalysts with Functional Ligands and Their Application in Difficult Dehydrogenation Reactions
  • Hideki Yorimitsu (Department of Chemistry, Graduate School of Science, Kyoto University, Professor)
    Aromatic Metamorphosis of Heteroarenes by Precisely Designed Catalysts
  • Mamoru Tobisu (Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Associate Professor)
    Catalytic Transformations of Unreactive Bonds Using N-Heterocyclic Carbene Ligands
  • Youhei Takeda (Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Associate Professor)
    Development of Synthetic Transformations of Saturated Cyclic Amines via the Oxidative Addition of C–N Single Bonds to Transition Metal Complexes as the Key Process
  • Yasuyuki Ura (Department of Chemistry, Biology, and Environmental Science, Faculty of Science, Nara Women’s University, Associate Professor)
    Development of anti-Markovnikov addition of oxygen nucleophiles to terminal alkenes
  • Ryo Yazaki (Graduate School of Pharmaceutical Sciences, Kyushu University, Assistant Professor)
    Development of Nucleophilic Activation Strategies for Highly Chemoselective Catalysis
  • Tatsuya Uchida (Faculty of Arts and Science, Kyushu University, Associate Professor)
    Development of Organic Material Transformation via New O2 Activation Method
  • Tetsuya Satoh (Department of Chemistry, Graduate School of Science, Osaka City University, Professor)
    Development of Molecular Transformation Involving Decarboxylation/Carboxylation on Porous Reaction Field
  • Takuya Kochi (Department of Chemistry, Faculty of Science and Technology, Keio University, Assistant Professor)
    Asymmetric Functionalization of Prochiral Methylenes via Chain-Walking
  • Junichiro Yamaguchi (Department of Applied Chemistry, School of Advanced Science and Enginnering, Waseda University, Associate Professor)
    Development of Decarbonylative cross-coupling reaction of esters
  • Shinji Tanaka (Interdisciplinary Research Center for Catalytic Chemistry, National Institute of Advanced Industrial Science and Technology (AIST), Researcher)
    Research on O2 oxidation catalyst for fine-chemicals synthesis

Research Item A02: Precise Formation of Transition Metal Catalysts with Molecular Scaffolding

Board Members

  • Nobuharu Iwasawa (Department of Chemistry, School of Science, Tokyo Institute of Technology, Professor)
    Development of New Reactions Based on the Construction of Precisely Designed Multidentate Ligands
  • Masaya Sawamura (Department of Chemistry, Faculty of Science, Hokkaido University, Professor)
    Development of Highly Active Solid-Supported Metal Catalysts Based on New Immobilization Methods
  • Shigeki Matsunaga (Faculty of Pharmaceutical Sciences, Graduate School of Life Science, Hokkaido University, Professor)
    Design of Catalytically Active Sites for Multi-Centers Control and their Application to Organic Transformation
  • Sensuke Ogoshi (Department of Applied Chemistry, Graduate School Engineering, Osaka University, Professor)
    Molecular Transformation in Variable Volume Reaction Site

Participating Researchers

  • Takayoshi Arai (Department of Chemistry, Graduate School of Science, Chiba University, Professor)
    Catalytic Asymmetric Coupling Reaction of Small Molecules Using Multi-nuclear Reaction Sphere
  • Yasuhiro Yamashita (Department of Chemistry, School of Science, The University of Tokyo, Associate Professor)
    The Design and Application of Highly Modified Chiral Alkaline Metal Complexes as Strong Base Catalysts for Highly Stereoselective Reactions
  • Kounosuke Oisaki (Graduate School of Pharmaceutical Sciences, The University of Tokyo, Assistant Professor)
    Development of organoradical-conjugated metal complex oriented to catalytic inert bond transformations
  • Takashi Koike (Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Assistant Professor)
    Synthesis and Visible-Light-Induced Reaction of Photoredox Catalysts Bearing Extremely Electron-Withdrawing SF5 Group
  • Yoshihiro Miyake (Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Associate Professor)
    Development of molecular transformations using transition metal complexes with electron-accepting π-conjugated unit
  • Masato Kitamura (Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Professor)
    Development of Chiral Multidentate Ligands toward Precise Control of Metal Catalysts
  • Hiroto Yoshida (Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Associate Professor)
    Development of New Precisely Designed Catalysts Based on Copper–Main Group Metal Species
  • Shin Takemoto (Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Associate Professor)
    Creation of photoactive metalloligands and their metal complexes for realizing extremely difficult chemical transformations
  • Ken Kamikawa (Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Professor)
    The precise control of a reactive site in a half-metallocene catalyst and the synthesis of complex molecules
  • Naoya Kumagai (Institute of Microbial Chemistry, Chief Researcher)
    Development of Catalytic Asymmetric C–C Bond-Forming Reactions Using Alkylnitriles as Pronucleophiles

Research Item A03: Precise Formation of Catalysts with Biomolecular Scaffolding

Board Members

  • Takashi Hayashi (Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Professor)
    Construction of a New Catalyst Having a Protein Cavity as a Reaction Scaffold
  • Jun-ya Hasegawa (Institute for Catalysis, Hokkaido University, Professor)
    Developing and application of computational methods toward controlling the active site of bio-catalysts
  • Osami Shoji (Department of Chemistry, Graduate School of Science, Nagoya University, Associate Professor)
    Material Transformation Using Biocatalysts Assisted by External Additives
  • Hiroyasu Yamaguchi (Department of Macromolecular Science, Graduate School of Science, Osaka University, Professor)
    Creation of Novel Hybrid Catalysts by Introducing a Transition Metal Complex into an Antigen Binding Site of Monoclonal Antibody

Participating Researchers

  • Toshiyuki Moriuchi (Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Associate Professor)
    Functuonal Design of Highly Organized Reaction Fields based on Chirality Organization of Biomolecules
  • Nobutaka Fujieda (Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Assistant professor)
    Precisely designed catalysts with protein scaffold as a versatile ligand
  • Takashi Matsuo (Graduate School of Materials Science, Nara Institute of Science and Technology, Associate Professor)
    Development of Biocatalysts with dynamical reaction field conversion by conformational change of protein scaffold
  • Tadashi Ema (Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University, Professor)
    Precisely Designed Catalysts with Customized Scaffolding Utilizing the Cooperative Effect: Multi-functional Metalloporphyrin Complexes
  • Yoshio Hisaeda (Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Professor)
    Construction of Bioinspired Catalytic System with Specific Reaction Environment
  • Yutaka Hitomi (Department of Applied Chemistry, Graduate School of Science and Engineering, Doshisha University, Professor)
    Development of Selective Oxidation Catalysts that Precisely Recognize Substrates in a Size-tunable Space

Research Item A04: Precise Formation of Catalysts with Large Scale Molecular Scaffolding.

Board Members

  • Kazushi Mashima (Division of Chemistry, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, Professor)
    Precise Formation of Metal Cluster Catalysts with Synergistic Metal-to-metal Interaction
  • Kazuaki Ishihara (Department of Applied Chemistry, Chemical Engineering and Biotechnology, Graduate School of Engineering, Nagoya University, Professor)
    The development of stereoselective reactions induced by "supramolecular cavity"
  • Michinori Suginome (Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Professor)
    Design and Creation of New Chiral Reaction Environment Utilizing Helical Macromolecular Architectures

Participating Researchers

  • Tienan Jin (WPI-Advanced Institute for Materials Research, Tohoku University, Associate Professor)
    Chemical bond activation for molecular transformations using nanoporous metal catalysts as specified field
  • Ken Motokura (Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, Associate Professor)
    Precise Design of Catalytic Surface with Multi-active Sites through the “Site-Isolation” Concept
  • Kohsuke Ohmatsu (Institute of Transformative Bio-Molecules, Nagoya University, Associate Professor)
    Development of Supramolecular Ionic Chiral Catalysts for Hitherto Difficult Asymmetric Transformations
  • Naoki Ousaka (Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Lecturer)
    Development of Dynamically Planar-Chiral Supramolecular Asymmetric Catalysts
  • Norio Shibata (Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Professor)
    Reaction on the π-surface of fluoro-functionalized subphthalocyanines
  • Tetsuaki Fujihara (Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Assistant Professor)
    Development of Periphery-Functionalized Gigantic Ligands and Their Application to Transition-Metal Catalyzed Reactions
  • Takuya Hashimoto (Department of Chemistry, Graduate School of Science, Kyoto University, Assistant Professor)
    Precise design of a chiral catalyst which utilizes the unique property of a main group element
  • Mitsuhiro Arisawa (Department of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Associate Professor)
    Self-Assembled Multilayer-Stabilized Metal Nanoparticle Catalyst for Functional Molecular Synthesis: in-situ Metal Nanoparticle and Nanospace Simultaneous Organization
  • Norimitsu Tohnai (Department of Material and Life Science, Graduate School of Engineering, Osaka University, Associate Professor)
    Development of Supramolecular Nanoreactor with Designable Catalytic Porous Organic Salts
  • Yoshiko Miura (Department of Chemical Engineering, Graduate School of Engineering, Kyushu University, Professor)
    Reaction Field with Soft Gel and Process Chemistry
  • Kenji Hara (Department of Applied Chemistry, School of Engineering, Tokyo University of Technology, Professor)
    Unique Catalysis by Precisely Designed Molecular Assembly on Surface

Academic Collaborator

  • Kimihisa Yamamoto (Chemical Resources Laboratory, Tokyo Institute of Technology, Professor)

Non-governmental Advisory Members

  • Astellas Pharma Inc.
  • Koei Chemical Co., Ltd.
  • Sanyo Chemical Industries, Ltd.
  • Sumitomo Chemical Company, Limited
  • DAIICHI SANKYO COMPANY, LIMITED
  • Takasago International Corporation
  • Tokuyama Corporation
  • TOYOTA CENTRAL R&D LABS., INC.
  • NIPPON SHOKUBAI CO., LTD.
  • FUJIFILM Corporation
  • Mitsui Chemicals, Inc.
  • Mitsubishi Chemical Group Science and Technology Research Center, Inc.
  • MITSUBISHI RAYON CO.,LTD.

International Advisory Board Members

  • Theodor Agapie (California Institute of Technology, United States)  
  • Jean-François Carpentier (Université de Rennes 1, France)
  • Sukbok Chang (KAIST, Korea)
  • Chien-Hong Cheng (National Tsing Hua University, Taiwan)
  • Paul J. Chirik (Princeton University, United States)
  • Christophe Coperet (ETH Zürich, Switzerland)
  • Deryn Fogg (University of Ottawa, Canada)
  • Alois Fürstner (Max-Planck-Institut für Kohlenforschung, Germany)
  • John Hartwig (University of California, Berkeley, United States)
  • Amir H. Hoveyda (Boston College, United States)
  • Jerzy Klosin (Dow Chemical Company)
  • Ruben Martin (Institute of Chemical Research of Catalonia, Spain)
  • Philip Mountford (Oxford University, U.K.)
  • Jun Okuda (RWTH Aachen University, Germany)
  • Gerard Roelfes (University of Groningen, Netherlands)
  • Thomas Ward (University of Basel, Switzerland)
  • Qi-Lin Zhou (Nankai University, China)