Groups and Members

In this research area, as shown in Figure 2, the following four research items cooperatively collaborate with each other to introduce innovation in the field of catalytic synthetic organic chemistry. Intensive studies will be performed to install the appropriate functions of suitable steric and electronic properties into a specific field around a catalytically active site.

Executive Board Members

Head Investigator,
A04 Group Director
Kazushi Mashima
Division of Chemistry, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, Professor
Collaborative Research Manager,
A01 Group Director
Kyoko Nozaki
Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Professor
Public Relations Manager,
A02 Group Director
Nobuharu Iwasawa
School of Science and Engineering, Tokyo Institute of Technology, Professor
Secretariat,
A03 Group Director
Takashi Hayashi
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Professor
Internationalization Manager Yoshiaki Nakao
Department of Material, Graduate School of Engineering, Kyoto University, Professor
Public Relations Manager Shigeki Matsunaga
Faculty of Pharmaceutical Sciences, Graduate School of Life Science, Hokkaido University, Professor
Internationalization Manager Osami Shoji
Department of Chemistry, Graduate School of Science, Nagoya University, Associate Professor

Advisory Board Members

Masakazu Iwamoto
Chuo University, RDI Professor; Tokyo Institute of Technology, Professor Emeritus; Hokkaido University, Professor Emeritus
Koichiro Oshima
Kyoto University, Vice President; Graduate School of Advanced Integrated Studies in Human Survivability, Professor
Naoto Chatani
Graduate School of Engineering, Osaka University, Professor
Tamejiro Hiyama
Chuo University, RDI Professor; Kyoto University; Professor Emeritus
Shunichi Fukuzumi
Faculty of Science and Technology, Meijo University, Specially Appointed Professor; Ewha Womans University, Distinguished Professor; Osaka University; Professor Emeritus
Keiji Maruoka
Graduate School of Science, Kyoto University, Professor
Masahiko Yamaguchi
Graduate School of Pharmaceutical Sciences, Tohoku University, Professor
Yoshihito Watanabe
Nagoya University, Vice President

Research Item A01: Development of Extremely Difficult Substrate Conversion

Board Members

  • Kyoko Nozaki (Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Professor)
    Development of Difficult Substrate Conversion Reaction toward Carbon Dioxide Utilization
  • Noritaka Mizuno (Department of Applied Chemistry, School of Engineering, The University of Tokyo, Professor)
    Development of High Performance Molecular Catalysts for Extremely Difficult Selective Oxidation Reactions
  • Yoshiaki Nishibayashi (Department of Systems Innovation, Graduate School of Engineering, The University of Tokyo, Professor)
    Development of Novel Transformations of Molecular Dinitrogen and Dihydrogen
  • Yoshiaki Nakao (Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Professor)
    Studies on Extremely Difficult Substrate Conversion Reactions through Activation of Unreactive Bonds

Participating Researchers

  • Hidetoshi Tokuyama (Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Professor)
    Development and application of environmentally benign oxidation process based on fine design of catalytic system using metal-phthalocyanine complexes
  • Yoshiharu Iwabuchi (Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Professor)
    Development of highly chemoseletive aerobic alcohol oxidation system based on AZADO-Cu cooperative catalysis
  • Seiji Mori (College of Science, Ibaraki University, Professor)
    Theoretical design of Extremely Difficult and Selective Substrate Conversion Reactions
  • Junji Ichikawa (Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Professor)
    Carbon-fluorine bond activation via fluorine eliminations
  • Hideki Amii (Division of Molecular Science, Graduate School of Science and Technology, Gunma University, Professor)
    Precisely Designed Catalyst Systems for Useful Transformation of Fluorocarbons
  • Yasuhiro Ohki (Department of Chemistry, Graduate School of Science, Nagoya University, Associate Professor)
    Precise Formation of Dinuclear Organometallic Reaction Sites and their Application in Difficult Substrate Reductions
  • Susumu Saito (Department of Chemistry, Graduate School of Science, Nagoya University, Professor)
    Catalytic dehydrative functionalization of amino acid- and peptide derivatives through elaborated hydrogen transfer processes
  • Takuya Kurahashi (Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Associate Professor)
    Development of extremely difficult substrate conversion based on modification of reaction pathway with "two-state reactivity" induced by spin-crossover
  • Hideki Yorimitsu (Department of Chemistry, Graduate School of Science, Kyoto University, Professor)
    Aromatic Metamorphosis of Heteroarenes by Precisely Designed Catalysts
  • Ken-ichi Fujita (Department of Interdisciplinary Environment, Graduate School of Human and Environmental Studies, Kyoto University, Professor)
    Design and Synthesis of New Transition Metal Catalysts with Functional Ligands and Their Application in Difficult Dehydrogenation Reactions
  • Mamoru Tobisu (Department of Applied Chemistry, Osaka University, Professor)
    Catalytic Transformations of Unreactive Bonds Using N-Heterocyclic Carbene Ligands
  • Takashi Nishikata (Graduate School of Sciences and Technology for Innovation, Yamaguchi University, Associate professor)
    The formation of a radical reaction field near an aromatic C-H bond for extremely difficult alkylations
  • Ryo Yazaki (Graduate School of Pharmaceutical Sciences, Kyushu University, Assistant Professor)
    Development of Nucleophilic Activation Strategies for Highly Chemoselective Catalysis
  • Tatsuya Uchida (Faculty of Arts and Science, Kyushu University, Associate Professor)
    Development of Organic Material Transformation via New O2 Activation Method
  • Masanari Kimura (Division of Chemistry and Materials Science, Graduate School of Engineering, Nagasaki University, Professor)
    Development of Efficient Synthesis of Fine Chemicals by Using Phoshine-Borane Ligands
  • Tetsuya Satoh (Department of Chemistry, Graduate School of Science, Osaka City University, Professor)
    Development of Molecular Transformation Involving Decarboxylation/Carboxylation on Porous Reaction Field
  • Takuya Kochi (Department of Chemistry, Faculty of Science and Technology, Keio University, Associate Professor)
    Asymmetric Functionalization of Prochiral Methylenes via Chain-Walking
  • Junichiro Yamaguchi (Department of Applied Chemistry, School of Advanced Science and Enginnering, Waseda University, Professor)
    Development of Decarbonylative cross-coupling reaction of esters
  • Naoya Kumagai (Institute of Microbial Chemistry, Chief Researcher)
    Development of Catalytic Asymmetric C–C Bond-Forming Reactions Using Alkylnitriles as Pronucleophiles
  • Laurean Ilies (RIKEN Center for Sustainable Resource Science, Team Leader)
    Design of Iron Catalyst for Activation of Simple Arenes and Heteroarenes

Research Item A02: Precise Formation of Transition Metal Catalysts with Molecular Scaffolding

Board Members

  • Nobuharu Iwasawa (School of Science and Engineering, Tokyo Institute of Technology, Professor)
    Development of New Reactions Based on the Construction of Precisely Designed Multidentate Ligands
  • Masaya Sawamura (Department of Chemistry, Faculty of Science, Hokkaido University, Professor)
    Development of Highly Active Solid-Supported Metal Catalysts Based on New Immobilization Methods
  • Shigeki Matsunaga (Faculty of Pharmaceutical Sciences, Graduate School of Life Science, Hokkaido University, Professor)
    Design of Catalytically Active Sites for Multi-Centers Control and their Application to Organic Transformation
  • Sensuke Ogoshi (Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Professor)
    Molecular Transformation in Variable Volume Reaction Site

Participating Researchers

  • Kazuhiro Yoshida (Graduate School of Science, Chiba University, Associate Professor)
    Development of Metal Catalysts Bearing Planar Chiral Cyclic (Amino)(metallocenyl)carbene Ligands
  • Takayoshi Arai (Department of Chemistry, Graduate School of Science, Chiba University, Professor)
    Catalytic Asymmetric Coupling Reaction of Small Molecules Using Multi-nuclear Reaction Sphere
  • Kounosuke Oisaki (Graduate School of Pharmaceutical Sciences, The University of Tokyo, Lecturer)
    Development of organoradical-conjugated metal complex oriented to catalytic inert bond transformations
  • Yusuke Sunada (Institute of Industrial Science, The University of Tokyo, Associate Professor)
    Development of Extremely Difficult Substrate Conversion Reactions by the Cooperative Interaction Between Metal Center and Adjacent Reaction Sites
  • Takashi Koike (Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Assistant Professor)
    Synthesis and Visible-Light-Induced Reaction of Photoredox Catalysts Bearing Extremely Electron-Withdrawing SF5 Group
  • Fuyuhiko Inagaki (Graduate School of Medical Sciences, Kanazawa University, Associate Professor)
    Development of Z-Ligand toward Precise Control of a Metal Catalyst Having a Specified Field
  • Fumitoshi Shibahara (Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, Associate Professor)
    Development of New Molecular Scaffolding with Bulky and π-Accepting NHC Ligands
  • Yoshihiro Miyake (Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Associate Professor)
    Development of molecular transformations using transition metal complexes with electron-accepting π-conjugated unit
  • Masato Kitamura (Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Professor)
    Development of Chiral Multidentate Ligands toward Precise Control of Metal Catalysts
  • Shin Takemoto (Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Associate Professor)
    Creation of photoactive metalloligands and their metal complexes for realizing extremely difficult chemical transformations
  • Ken Kamikawa (Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Professor)
    The precise control of a reactive site in a half-metallocene catalyst and the synthesis of complex molecules
  • Yoshihiro Sohtome (Synthetic Organic Chemistry Laboratory, RIKEN, Senior Research Scientist)
    Centrochiral transition metal complexes for catalytic asymmetric reactions
  • Yumiko Nakajima (Interdisciplinary Research Center for Catalytic Chemistry, National Institute of Advanced Industrial Science and Technology, Team Leader)
    Development of low-spin Fe complexes with a highly-electron-rich reaction sphere and their application towards strong bond cleavage

Research Item A03: Precise Formation of Catalysts with Biomolecular Scaffolding

Board Members

  • Takashi Hayashi (Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Professor)
    Construction of a New Catalyst Having a Protein Cavity as a Reaction Scaffold
  • Jun-ya Hasegawa (Institute for Catalysis, Hokkaido University, Professor)
    Developing and application of computational methods toward controlling the active site of bio-catalysts
  • Osami Shoji (Department of Chemistry, Graduate School of Science, Nagoya University, Associate Professor)
    Material Transformation Using Biocatalysts Assisted by External Additives
  • Hiroyasu Yamaguchi (Department of Macromolecular Science, Graduate School of Science, Osaka University, Professor)
    Creation of Novel Hybrid Catalysts by Introducing a Transition Metal Complex into an Antigen Binding Site of Monoclonal Antibody

Participating Researchers

  • Yoshio Hisaeda (Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Professor)
    Construction of Bioinspired Catalytic System with Specific Reaction Environment
  • Nobutaka Fujieda (Graduate School of Life and Environmental, Osaka Prefecture University, Associate Professor)
    Precisely designed catalysts with protein scaffold as a versatile ligand
  • Yutaka Hitomi (Department of Applied Chemistry, Graduate School of Science and Engineering, Doshisha University, Professor)
    Development of Selective Oxidation Catalysts that Precisely Recognize Substrates in a Size-tunable Space

Research Item A04: Precise Formation of Catalysts with Large Scale Molecular Scaffolding.

Board Members

  • Kazushi Mashima (Division of Chemistry, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, Professor)
    Precise Formation of Metal Cluster Catalysts with Synergistic Metal-to-metal Interaction
  • Kazuaki Ishihara (Department of Applied Chemistry, Chemical Engineering and Biotechnology, Graduate School of Engineering, Nagoya University, Professor)
    The development of stereoselective reactions induced by "supramolecular cavity"
  • Michinori Suginome (Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Professor)
    Design and Creation of New Chiral Reaction Environment Utilizing Helical Macromolecular Architectures

Participating Researchers

  • Takuya Hashimoto (Department of Chemistry, Graduate School of Science, Chiba University, Associate Professor)
    Precise design of a chiral catalyst which utilizes the unique property of a main group element
  • Ken Motokura (Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, Associate Professor)
    Precise Design of Catalytic Surface with Multi-active Sites through the “Site-Isolation” Concept
  • Masahiko Inouye (Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Professor)
    Development of Macrocyclic Catalysts by Connecting Catalytic Moieties to Saccharide Recognition Macrocycles and their use for Successive Derivatization of Oligosaccharides
  • Naoki Ousaka (Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Lecturer)
    Development of Dynamically Planar-Chiral Supramolecular Asymmetric Catalysts
  • Tetsuaki Fujihara (Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Associate Professor)
    Development of Periphery-Functionalized Gigantic Ligands and Their Application to Transition-Metal Catalyzed Reactions
  • Keisuke Asano (Graduate School of Engineering, Kyoto University, Assistant Professor)
    Hydrogen Bonding Networks for Precisely Designed Cyclization Catalysis
  • Mitsuhiro Arisawa (Department of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Associate Professor)
    Self-Assembled Multilayer-Stabilized Metal Nanoparticle Catalyst for Functional Molecular Synthesis: in-situ Metal Nanoparticle and Nanospace Simultaneous Organization
  • Kenji Hara (Department of Applied Chemistry, School of Engineering, Tokyo University of Technology, Professor)
    Unique Catalysis by Precisely Designed Molecular Assembly on Surface
  • Norie Momiyama (Institute for Molecular Science, Associate Professor)
    Immobilization of Organocatalyst via Halogen Bond and Application to Construction of Chiral Reaction Medium

Academic Collaborator

  • Kimihisa Yamamoto (Chemical Resources Laboratory, Tokyo Institute of Technology, Professor)

Non-governmental Advisory Members

  • Astellas Pharma Inc.
  • Koei Chemical Co., Ltd.
  • Sanyo Chemical Industries, Ltd.
  • Sumitomo Chemical Company, Limited
  • DAIICHI SANKYO COMPANY, LIMITED
  • Daicel Corporation
  • Takasago International Corporation
  • Tokuyama Corporation
  • TOYOTA CENTRAL R&D LABS., INC.
  • NIPPON SHOKUBAI CO., LTD.
  • NIHON NOHYAKU CO.,LTD.
  • FUJIFILM Corporation
  • Mitsui Chemicals, Inc.
  • Mitsubishi Chemical Group Science and Technology Research Center, Inc.
  • Mitsubishi Chemical Corporation

International Advisory Board Members

  • Theodor Agapie (California Institute of Technology, United States)  
  • Jean-François Carpentier (Université de Rennes 1, France)
  • Sukbok Chang (KAIST, Korea)
  • Chien-Hong Cheng (National Tsing Hua University, Taiwan)
  • Paul J. Chirik (Princeton University, United States)
  • Christophe Coperet (ETH Zürich, Switzerland)
  • Deryn Fogg (University of Ottawa, Canada)
  • Alois Fürstner (Max-Planck-Institut für Kohlenforschung, Germany)
  • John Hartwig (University of California, Berkeley, United States)
  • Amir H. Hoveyda (Boston College, United States)
  • Jerzy Klosin (Dow Chemical Company)
  • Ruben Martin (Institute of Chemical Research of Catalonia, Spain)
  • Philip Mountford (Oxford University, U.K.)
  • Jun Okuda (RWTH Aachen University, Germany)
  • Gerard Roelfes (University of Groningen, Netherlands)
  • Thomas Ward (University of Basel, Switzerland)
  • Qi-Lin Zhou (Nankai University, China)